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Gefitinibs single-agent activity in a group consisting of pretreated NSCLC patients is confirmed. Side-effects of gefitinib were mild. Prolonged survival was associated with good PS and less significantly with a never-smoking history, female gender and histology. Additional studies on mechanisms of tumor control and selection of target populations for this remarkable new drug are warranted.
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Breast Cancer and the Use of Statins; Warnings Issued for IBS Drugs; FDA Actions
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In a phase II trial, the combination of low-dose carboplatin and paclitaxel was shown to be well tolerated by elderly and, or frail (ECOG performance status 2) patients with advanced small cell lung cancer. Response rates and survival were comparable to those published for other combinations.
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The first part of this series reviews cervical spine immobilization, patient selection for imaging and clinical decision rules for cervical spine radiography. This two-part article is critical for any physician who manages patients with potential cervical spine trauma.
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The MATCH data provide quite strong evidence that the clopidogrel-aspirin combination is a less favorable option than previously thought, but its use may not be completely contraindicated.
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The means by which prions cause neuropathologic damage remains to be established.
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Any time the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) adds a new requirement to the survey process, quality professionals are obligated to become conversant with it to ramp up for their next survey. But if thats all the new tools are used for, they may be missing significant opportunities for improvement, experts argue. Such is the case with tracer methodology.
